REVIEW
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Xenotransplantation 2013: 20: 148-156
Screening
pigs for Xenotransplantation :
prevalence and
expression of porcine endogenous
retroviruses in Göttingen
minipigs
Marwan Semaan, Avi Rotem, Uriel Barkai, Stefan Bornstein
and Joachim Denner
- Xenotransplantation 2013: 20: 148-156 Screening pigs for Xenotransplantation : prevalence and expression of porcine endogenous retroviruses in Göttingen minipigs Marwan Semaan, Avi Rotem, Uriel Barkai, Stefan Bornstein and Joachim Denner By Natassha Jamil Bsc. (Hons.) Biomolecular Science Free Powerpoint Templates Page 1 <br>
- Introduction Xenotransplantation using pig cells, tissues and organ has overcome the shortage of organ for transplantation (Ekser et al., 2012). Free Powerpoint Templates Page 2 <br>
- All pig genome integrated with Porcine endogenous retrovirus (Fishman, 2001) • Can be released as infectious particles - infect human cells (Wilson, 2008) PERV A and PERV B infect human cells but also other species cell in vitro (Takeuchi et al., 1998). Endogenous Retrovirus (Takeuchi et al.2005). PERV C is an virus infecting only pig cells and not present in all pig genome (Takeuchi et al., 1998) Free Powerpoint Templates Page 3 <br>
- However, recombinant PERV A/C infecting human cells and replicating at higher rate compare to PERV A (Harrison et al., 2004) • Different multitransgenic pigs were generated (Phelps et al., 2003) • To decrease risk of immunological transplant rejection and transmission of porcine microorganisms (Klymiuk et al., 2010) Free Powerpoint Templates Page 4
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